Jeffrey Gordon — Center Director

Genomic and metabolic foundations of symbiotic host-microbial relationships in the mammalian gut. Lab Website

Megan Baldridge

Megan’s research explores the regulation of viral and bacterial pathogens by commensal bacteria and the host innate immune system. Her lab also characterizes how pathogens evolve to evade host control and benefit from the presence of other microbes. Lab Website

Michael Brent

Michael is interested in modeling networks that regulate cell state on both a detailed, kinetic level and a genome-wide level. Detailed models are aimed at understanding how the responses of specific gene regulatory networks unfold over time and predicting how their responses will be affected by genetic modifications. Genome-wide modeling efforts are aimed inferring regulatory networks in organisms whose gene regulation has not been mapped in detail. The Brent lab approaches gene regulation systems using both computational and experimental methods. Lab Website

Barak Cohen – Ruffian, Scallywag, Systems Biologist

Cohen ruthlessly manipulates and bullies tiny yeast cells into giving up what they know about the molecular mechanisms that underlie the operation of complex genetic regulatory networks. Lab Website

Gautam Dantas

Gautam’s lab develops novel technologies to understand and engineer the biochemical processing potential of the microbial world. They work at the interface of microbial genomics and biochemistry, synthetic biology and structural biology to study problems with biotechnological and biomedical relevance, with a specific focus on understanding microbial reservoirs of antibiotic resistance and engineering microbial catalysis of plant biomass into value chemicals. Lab Website

Todd Druley

As a pediatric oncologist, Todd’s research is focused on understanding the impact of rare genetic variation on complex disease – particularly childrens’ cancer.  Lab members are developing technology and informatics to leverage the latest in DNA sequencing technology in order to study the role of rare variants in a variety of pediatric and adult complex diseases. Lab Website

Scott Handley

Scott’s research focuses on using computational tools to analyze microbial ecology in the context of health and disease. In particular, his lab investigates how viral, fungal and bacterial communities affect chronic (IBD, IBS) and infectious (HIV, flavivurses, rotavirus) diseases.

Robi Mitra

Technology development for functional genomics and systems biology. Lab Website

Michael Province

Mathematical development of new statistical genetics methodology for complex traits. Lab Website

Gary Stormo

Gary Stormo uses experimental and computational approaches to model the binding specificity of transcription factors which allows for the prediction of gene regulatory networks. He is also interested in modeling how the specificity changes when the protein sequence changes, which can lead to the design of new proteins with novel specificity. Lab Website

Ting Wang

Ting Wang is interested in how regulatory networks evolve and adapt, and how disturbance of the network may lead to human diseases, including cancer. His current focus is investigating genetic and epigenetic impact of transposable elements on mammalian regulatory networks. Lab Website