Jeffrey Gordon — Center Director
Genomic and metabolic foundations of symbiotic host-microbial relationships in the mammalian gut. Lab Website
Dustin Baldridge
Dustin’s lab studies the genetic basis of rare Mendelian disorders and develops high-throughput cell-based assays and functional genomics techniques to experimentally characterize the effects of clinically observed variants. Lab Website
Megan Baldridge
Megan’s research explores the regulation of viral and bacterial pathogens by commensal bacteria and the host innate immune system. Her lab also characterizes how pathogens evolve to evade host control and benefit from the presence of other microbes. Lab Website
Michael Brent
My lab focuses on mapping transcriptional regulatory networks and modeling them quantitatively. We develop general methods and apply them to understanding specific biological systems including baker’s yeast and Cryptococcus neoformans, a fungal pathogen. We also work on identifying genetic variants that affect important phenotypes, including human lifespan. Lab Website
Barak Cohen – Ruffian, Scallywag, Systems Biologist
Cohen ruthlessly manipulates and bullies tiny yeast cells into giving up what they know about the molecular mechanisms that underlie the operation of complex genetic regulatory networks. Lab Website
Gautam Dantas
Gautam’s lab develops novel technologies to understand and engineer the biochemical processing potential of the microbial world. They work at the interface of microbial genomics and biochemistry, synthetic biology and structural biology to study problems with biotechnological and biomedical relevance, with a specific focus on understanding microbial reservoirs of antibiotic resistance and engineering microbial catalysis of plant biomass into value chemicals. Lab Website
Scott Handley
Scott’s research focuses on using computational tools to analyze microbial ecology in the context of health and disease. In particular, his lab investigates how viral, fungal and bacterial communities affect chronic (IBD, IBS) and infectious (HIV, flavivurses, rotavirus) diseases.
Robi Mitra
Technology development for functional genomics and systems biology. Lab Website
Brian Muegge
Brian’s lab is interested in the genetic and metabolic regulation of cell fate decisions. We are especially focused on defining how stem cells in the gut give rise to the diverse intestinal epithelial endocrine system, because the hormones made by these cells are important in the treatment of obesity and type 2 diabetes. Their work is at the interface of computational genomics, developmental biology, and cellular models of disease, and we combine experimental and computational methods to discover new uses for gut hormones to improve human health. Lab Website
Michael Province
Mathematical development of new statistical genetics methodology for complex traits. Lab Website
Gary Stormo
Gary Stormo uses experimental and computational approaches to model the binding specificity of transcription factors which allows for the prediction of gene regulatory networks. He is also interested in modeling how the specificity changes when the protein sequence changes, which can lead to the design of new proteins with novel specificity. Lab Website
Ting Wang
Ting Wang is interested in how regulatory networks evolve and adapt, and how disturbance of the network may lead to human diseases, including cancer. His current focus is investigating genetic and epigenetic impact of transposable elements on mammalian regulatory networks. Lab Website